Abstract
We compared the fever-reducing efficacy of acetaminophen (AA), ibuprofen (IBU), and dexibuprofen (DEX) using data collected from the mobile healthcare application FeverCoach, which provides parents with guidelines for determining their child’s health condition, according to body temperature. Its dataset includes 4.4 million body temperature measurement records and 1.6 million antipyretics treatment records. Changes in body temperature over time were compared after taking one of three different antipyretics (AA, IBU, and DEX), using a one-way ANOVA followed by a post-hoc analysis. A multivariate linear model was used to further analyze the average body temperature differences, calibrating for the influences of age, weight, and sex. Children administered IBU had average body temperatures that were 0.18 °C (0.17–0.19 °C), 0.25 °C (0.24–0.26 °C), and 0.18 °C (0.17–0.20 °C) lower than those of children administered AA, at time intervals of 1–2 hours, 2–3 hours, and 3–4 hours, respectively. Similarly, children administered DEX had average body temperatures that were 0.24 °C (0.24–0.25 °C), 0.28 °C (0.27–0.29 °C), and 0.12 °C (0.10–0.13 °C) lower than those of children administered AA, at time intervals of 1–2, 2–3, and 3–4 hours, respectively. Although the data were collected from the application by non-professional parents, the analysis showed that IBU and DEX were more effective in reducing body temperature than AA was.
Highlights
We compared the fever-reducing efficacy of acetaminophen (AA), ibuprofen (IBU), and dexibuprofen (DEX) using data collected from the mobile healthcare application FeverCoach, which provides parents with guidelines for determining their child’s health condition, according to body temperature
Infectious agents, microbial products, or both as well as cytokines and other inflammatory processes induce macrophages, endothelial cells, and the reticuloendothelial system to synthesize and release pyrogenic cytokines such as interleukin (IL)-1 and IL-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-β and IFN-γ2. These cytokines cause the synthesis of prostaglandin E2 (PGE2), which binds to prostaglandin receptors in the hypothalamus to raise the thermostatic set point to febrile levels
We conducted a one-way analysis of variance (ANOVA) to determine whether there were differences in body temperature between the groups administered AA, IBU, and DEX at each time interval
Summary
We compared the fever-reducing efficacy of acetaminophen (AA), ibuprofen (IBU), and dexibuprofen (DEX) using data collected from the mobile healthcare application FeverCoach, which provides parents with guidelines for determining their child’s health condition, according to body temperature. Infectious agents, microbial products, or both as well as cytokines and other inflammatory processes induce macrophages, endothelial cells, and the reticuloendothelial system to synthesize and release pyrogenic cytokines such as interleukin (IL)-1 and IL-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-β and IFN-γ2 These cytokines cause the synthesis of prostaglandin E2 (PGE2), which binds to prostaglandin receptors in the hypothalamus to raise the thermostatic set point to febrile levels. AA is recommended at doses of Variable Weight (kg) Intake (mg/kg) Ratio of male sex Age (days)
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