Comparison of fasting and non-fasting blood lipid levels in children in Tianjin

Abstract

Objective To compare the difference between fasting blood lipids and non-fasting blood lipids in children in Tianjin, and to explore the feasibility of non-fasting blood lipids detection in children. Methods A total of 223 child patients were enrolled in Department of Pediatrics, the Second Hospital of Tianjin Medical University from January 2017 to February 2018, fasting and 1-6 h post-dining blood samples were collected from each patient.Total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured.Self-control methods were used.Wilcoxon signed rank test was used for statistical analysis. Results Compared with fasting lipids, non-fasting TC increased with 0.02 mmol/L, TG increased with 0.01 mmol/L, HDL-C increased with 0.03 mmol/L, while LDL-C decreased with 0.01 mmol/L, but non-high-density lipoprotein cholesterol did not change.Among them, only the difference in HDL-C between the fasting and non-fasting was statistically significant (Z=-2.870, P<0.05). The difference in the change rate of all indicators was <3%.According to the dyslipidemia group comparison, the differences in hypercholesterolemia (0.72 mmol/L, Z=-2.551, P=0.011), hypertriglyceridemia (0.73 mmol/L, Z=-3.846, P<0.001), low high-density lipoprotein cholesterolemia (-0.04 mmol/L, Z=-8.625, P<0.001) and normal level HDL-C (0.1 mmol/L, Z=-5.040, P<0.001)between non-fasting lipids and fasting blood lipids were statistically significant. Conclusions The change of children′s blood lipid profile in fasting and non-fasting conditions is little.Lipid testing in children does not require fasting.Blood tests can be performed at any appropriate time point in the normal diet. Key words: Non-fasting blood lipid; Blood lipid; Cardiovascular disease; Child