Abstract
Introduction: Hepatocellular carcinoma (HCC) is one of the most life threatening cancers in the world. The P16 protein is the product of tumour suppressor gene P16 that plays a role in the regulation of cell cycle and hence in progression of cancer. Method: Fifty rats were divided into three groups: DEN induced HCC group, phenobarbital induced HCC group, and control group. The rats were sacrified after fourteen weeks. The relative expression of P16 in liver tissue was measured. The liver enzymes were measured to confirm liver damage. Results: The relative expression of P16 was decreased in DEN induced HCC group than phenobarbital induced HCC group. It was confirmed by liver enzyme assay. Conclusion: The relative expression of P16 is a sign of the severity of HCC.
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