Abstract
Summary1. A modification of Minibeck's method was found to be satisfactory for the determination of cholic acid and glycocholic acid added to serum. 2. In healthy dogs when bromsulphthalein and sodium cholate were injected together, the concentration of bromsulphthalein in the serum was greatly elevated five and fifteen minutes after administration. The cholate concentration, however, was normal. 3. In early central necrosis of the liver produced by carbon tetrachloride, the bromsulphthalein excretion was definitely delayed while the cholate excretion was only slightly changed. The bromsulphthalein test appeared to be more sensitive in detecting early hepatic damage. During the first thirty minutes the bromsulphthalein retention in the combined test paralleled roughly the retention when bromsulphthalein was given alone, but was 35-60% higher.
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