Abstract
ISCR elements in S. maltophilia. Therefore, the possibility of trimethoprim resistance genes located on ISCR elements beyond class 1 integrons in clinical isolates in the present study merits further elucidation. However, chromosome-mediated trimethoprim resistance cannot be ruled out. Furthermore, selection of QAC resistance in the natural environment has the potential to co-select for antibiotic resistance. In this study, the incidence of trimethoprim/sulfamethoxazole resistance was significantly associated with the presence of QAC resistance genes carried on integrons. Therefore, it is possible that introduction of QAC into hospital settings to prevent bacterial infection might enhance the selection of trimethoprim/ sulfamethoxazole-resistant isolates. In conclusion, this study indicates that isolates with resistance to trimethoprim/sulfamethoxazole are associated with the presence of class 1 integrons and QAC resistance genes located on integrons.
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