Objective: To compare enhanced depth imaging optical coherence tomography (EDI-OCT) and swept source OCT (SS-OCT) images in Vogt-Koyanagi-Harada (VKH) disease to determine the agreement of subfoveal choroidal thickness (SFCT) measurements between them. Methods: SFCT of one eye of all consecutive VKH patients seen at the Singapore National Eye Centre during 2012 to 2013 was measured using both modalities by one masked trained observer. Charts were retrospectively reviewed for demographics, duration of disease and phase of disease. The acute phase was defined as being within the first 6 months of onset and the chronic phase any time thereafter. Results: 137 SS-OCT and EDI-OCT scans were obtained from 48 patients. Mean age was 52 years. Majority were Chinese (31 patients, 65%) and females (29,60%). The quality of SS-OCT images were superior to EDI-OCT during the acute phase but were similar in the chronic phase. There was good inter-OCT correlation for both the acute and the chronic phase (Mean difference in SFCT ± 2 standard deviation of -22.7 ± 39.4 microns and -13.0 ± 42 microns respectively).The mean SFCT was greater the in acute phase (352.4 microns, SD 89.5) than in the chronic phase (221.5 microns, SD116.1, P<0.001) and became less with increasing age and duration of disease (Spearman’s rho -0.60 and -0.64 respectively, P<0.001). Conclusion: SS-OCT provides much better resolution images of the choroid than EDI-OCT resulting in more measurable images. There was good agreement of SFCT measurements between the two modalities when both sets of images were measurable.

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