Comparison of Egg Yolk and Soybean Phospholipids on Hepatic Fatty Acid Profile and Liver Protection in Rats Fed a High-Fructose Diet.

Mingyu Yin,Xichang Wang,Yinci Xi,Ryosuke Matsuoka

doi:10.3390/foods10071569

Abstract

Perturbed lipid metabolism leads to ectopic lipid accumulation in tissues, such as the liver, thereby causing nonalcoholic fatty liver disease (NAFLD) and negatively influencing circulating lipid profile-inducing dyslipidemia. Phospholipids (PLs) with special biological activity are used to treat chronic diseases such as cardiovascular and cerebrovascular disease. PLs derived from egg yolk and soya bean have significant antioxidant and lipid-lowering abilities. This study examined the therapeutic effects of them on hyperlipidemia using a high-fructose-fed rat model; lipid metabolism and anti-inflammatory effects were also analyzed. The results showed that both egg yolk and soya bean phospholipids (EPLs and SPLs) reduced liver weight, hepatic TG, and MDA content as well as serum ALT, AST, TBA, and CRP levels (p < 0.05). The PLs also showed hypolipidemic and anti-inflammatory effects. EPLs and SPLs could inhibit the accumulation of hepatic fatty acids C18:1N9C, C18:0, and C22:6NS of rats fed a high-fat-and-sucrose diet. The intake of EPLs could significantly increase acetylcholine content in the blood and brain tissue. Histological examination showed that PLs intake could ameliorate the damage to liver tissue. This study suggested that EPLs and SPLs had a certain capacity of hypolipidemic and liver protection, and the therapeutic benefits of EPLs tended to be more effective than that of soybean phospholipids.

Highlights

Chronic diseases such as coronary heart disease, diabetes, nonalcoholic fatty liver disease (NAFLD), and cancer seriously threaten human health and reduce family happiness indices [1,2]
Egg yolk PLs (EPLs) significantly blocked the significant increase in the body weight, food efficiency, liver weight, and abdominal fat weight compared to the model group, whereas administration of soybean PLs (SPLs) did not exhibit any alterations in body weight and abdominal fat weight without significant differences compared with the model group, which were significantly higher than the EP group (p < 0.05)
PLs, by preventing the negative effects of the high-fructose diet, ameliorate liver damage and decrease circulating transaminases. These results further suggest that exogenous PL can counteract lipid metabolism disorders and inflammation caused by HFD

Summary

Introduction

Chronic diseases such as coronary heart disease, diabetes, nonalcoholic fatty liver disease (NAFLD), and cancer seriously threaten human health and reduce family happiness indices [1,2]. Hyperlipidemia represents several different disorders of lipid metabolism related to increased production or delayed degradation of atherogenic lipoprotein particles, or decreased synthesis or increased degradation of protective lipoprotein particles [4]. These alterations lead to pathological changes in the lipid levels in various tissues of the body. A number of studies indicated that marine fish oils, peptides, and polyphenols in natural substances can help restore serum lipid status, decrease the activity of transaminase, and reduce the occurrence of chronic disease [8]. Note: Commercial standard chow (control group), high-fructose group (model group), an HFD containing 2% egg PLs (egg yolk phospholipids group, EP), and an HFD containing 2% soy PLs (soybean phospholipids group, SP)

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Results

Conclusion