Abstract
Objectives:To compare the efficacy of tranexamic acid mesotherapy versus 0.9% normal saline for melasma by split-face study.Methods:It was a non-randomized clinical trial performed at the Dermatology ward of JPMC from September 2018 to June 2019 after getting approval from the Ethical Committee. A total of sixty patients were recruited in the study, who had symmetrical melasma on their faces. Both halves of the face were treated by Injection Tranexamic Acid (TA) with a dose of 4mg/ml and Normal Saline (NS) two weekly for twelve weeks. Hemi Modified Melasma Area and Severity Scoring (H-mMASI) was calculated at the start and end of the study. Analyses were done by SPSS version 23. P < 0.05 was taken as significant.Results:Mean of H-mMASI score was compared on both sides at the end of study, which showed significant reduction in mean score from 3.19 ±2.57 to 1.52 ± 1.2 (P < 0.05) on A side as compared to decline in scores on NS side from 3.46 ± 2.7 to 3.45 ± 2.6 (P > 0.05). Erythema, swelling, and burning were documented as temporary side effects on both sides.Conclusion:Tranexamic Acid (TA) mesotherapy can be considered as the most cost-effective, safe and directly observed therapy for melasma which showed significant improvement when old prior therapies have failed.
Highlights
Melasma is an acquired disorder of hyperpigmentation of skin, which symmetrically affects the face.[1]
No study has been conducted so far in Pakistan to determine the exact burden of melasma, one study in Pakistan showed prevalence of 45% in pregnant women.[3,4]
Patients who had any medical illness, bleeding disorder, on anticoagulant therapy, pregnant females, lactating mothers or those who used topical treatment for melasma in last one month were excluded from the study
Summary
Melasma is an acquired disorder of hyperpigmentation of skin, which symmetrically affects the face.[1] It is defined as dark hyperpigmented patches, which becomes more pronounced after sun exposure.[2] Globally, prevalence of melasma ranges between 1–50%, while prevalence in Arab-American populations is 13.4–15.5%.1. No study has been conducted so far in Pakistan to determine the exact burden of melasma, one study in Pakistan showed prevalence of 45% in pregnant women.[3,4]. Melasma is one of the chronic and relapsing disorders of skin. It causes depression and frustration in patients, which had worse impact
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