Abstract

Objective: To compare the efficacy of methotrexate versus acitretin in the treatment of chronic plaque psoriasis Method: Randomized controlled Trial conducted in Dermatology Department, Services Hospital Lahore, on 60 patients after informed consent, divided into two groups. Group A given methotrexate 0.30.5mg/kg orally and group B given acitretin 0.4mg/kg orally. Efficacy was ascertained by reduction in PASI score, calculated at baseline and at the 12 weeks. Results:Patients of Group A achieved a reduction in PASI score from baseline 13.13±2.047 to 6.20±2.024 (efficacy 76.7%) while in Group B, PASI score dropped from 13.53±2.047 to 7.00±1.857 (efficacy 56.7%). Adverse effects for both groups were minimal and as expected. Conclusion: Both methotrexate and acitretin are highly effective drugs in treating chronic plaque psoriasis. However, methotrexate shows greater efficacy and faster reduction in PASI as compared to acitretin.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call