Abstract
目的比较阿托伐他汀和普伐他汀治疗原发性高脂血症的疗效和安全性.方法 61例原发性高脂血症的患者随机分两组,阿托伐他汀组32例,10 mg/d口服;普伐他汀组29例,20 mg/d口服.疗程8周,观察降脂疗效和不良反应.结果阿托伐他汀组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)与治疗前比较均有显著下降(P＜0.01),阿托伐他汀组降低TC、LDL-C的作用优于普伐他汀组(P＜0.05).两组不良反应相似,均较轻微.结论阿托伐他汀治疗原发性高脂血症的疗效明显优于普伐他汀,不良反应轻微,耐受性良好.
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