Comparison of efficacy and safety of keto profen patch versus diclofenac patch as preemptive analgesia in patients undergoing inguinal hernia surgeries

Abstract

Background: This study was conducted to compare the efficacy and safety of ketoprofen versus diclofenac patch for pre-emptive analgesia in patients undergoing inguinal hernia surgeries. Method: This was a prospective, randomized, comparative clinical study conducted at MGM and MY groups of hospital, Indore, MP. 60 male patients of ASA grade 1 and 2 undergoing inguinal hernia surgeries were divided into N=30 each. Sample size calculation was based on the difference of mean of two independent samples. Trans- dermal patches of ketoprofen and diclofenac sodium were applied to the participants in both the study groups one hour prior to the induction of anesthesia. Postoperative pain was assessed using VAS and VRS at 2,4,8,12,16 and 24 hours. Result: Mean VAS in ketoprofen group was (2.88 ± 0.67) which was significantly low (P value less than 0.05) as compared to the diclofenac group (3.42 ± 0.17). Likewise, VRS mean in ketoprofen group (1.60 ± 0.34) was low as compared to diclofenac group (1.81 ± 0.23) suggesting better efficacy of ketoprofen patch over diclofenac patch. Data were analysed using unpaired students T test. Conclusion: In our study we found ketoprofen patch as better analgesic then diclofenac patch for post-operative hernia surgeries pain. Also the transdermal route is very comfortable for the patient compared to oral, intramuscular, intravenous route for pain alleviation.