Abstract
Comparison of Efficacy & Safety Between Intravenous and Intraarticular Tranexamic Acid in Reducing Blood Loss after Total Knee Arthroplasty
Highlights
Perioperative blood loss has been a problem in contemporary arthroplasty because up to 1000 mL to 1500 mL of blood is commonly lost and the consequences of such blood loss impact negatively on both the individual patient and the healthcare system in general, as it may be associated with symptomatic anaemia requiring blood transfusion[1,2]
Its application transiently activates fibrinolysis by enhancing the release of tissue plasminogen activator (t-PA) which is responsible for significant postoperative blood loss following total knee arthroplasty
A total of 74 total knee arthroplasties were performed on 64 patients
Summary
Perioperative blood loss has been a problem in contemporary arthroplasty because up to 1000 mL to 1500 mL of blood is commonly lost and the consequences of such blood loss impact negatively on both the individual patient and the healthcare system in general, as it may be associated with symptomatic anaemia requiring blood transfusion[1,2]. Blood transfusion is a life-saving procedure in acute hemorrhage. It is expensive and associated with many hazards including risk of infections, immune suppression, anaphylaxis, volume overload, and transfusion - related lung injury, to mention just a few[3]. Various methods have been tried to reduce perioperative blood loss; including tourniquet use, hypotensive anesthesia, intraoperative blood. Arojuraye SA et al Tranexamic Acid in Reducing Blood Loss after TKA salvage, and the use of diathermy[4]. Total knee arthroplasty (TKA), is often carried out using a tourniquet to minimize intraoperative blood loss. Its application transiently activates fibrinolysis by enhancing the release of tissue plasminogen activator (t-PA) which is responsible for significant postoperative blood loss following total knee arthroplasty. The use of antifibrinolytic drugs such as tranexamic acid has been established to reduce this complication[5]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
