Abstract
The aim of this study was to compare the effect of propofol and ketofol (ketamine-propofol mixture) on EA in children undergoing tonsillectomy. In this randomized clinical trial, 87 ASA class I and II patients, aged 3-12 years, who underwent tonsillectomy, were divided into two groups to receive either propofol 100 µg/kg/min (group p, n=44) or ketofol : ketamine 25 µg/kg/min + propofol 75 µg/kg/min (group k, n= 43). Incidence and severity of EA was evaluated using the Pediatric Anesthesia Emergence Delirium (PAED) scales on arrival at the recovery room, and 10 and 30 min after that time. There was no statistically significant difference in demographic data between the two groups. In the ketofol group, the need for agitation treatment and also mean recovery duration were lower than in the propofol group (30 and 41%, and 29.9 and 32.7 min), without statistically significant difference (P value=0.143 and P value=0.187). Laryngospasm or bronchospasm occurred in 2 patients in each group and bleeding was observed in only one individual in the ketofol group. Infusion of ketofol in children undergoing tonsillectomy provides shorter recovery time and lower incidence of EA despite the non significant difference with propofol.
Highlights
Emergence agitation (EA) was first described by Eckenhoff in the 1960s and is a condition that can occur duringAfrican Health SciencesAfrican Health Sciences Vol 19 Issue 1, March, 2019 occurs within the first 30 min of stay in post anesthesia care unit, it may last up to 2 days
Background: The aim of this study was to compare the effect of propofol and ketofol on EA in children undergoing tonsillectomy
It has been shown that when propofol is used for maintenance of anesthesia, it reduces the incidence of EA13-18
Summary
Emergence agitation (EA) was first described by Eckenhoff in the 1960s and is a condition that can occur duringAfrican Health SciencesAfrican Health Sciences Vol 19 Issue 1, March, 2019 occurs within the first 30 min of stay in post anesthesia care unit, it may last up to 2 days. A mixture of ketamine and propofol reduces the sedative effect of propofol with lower toxicity as compared to each drug by reduction in the required doses. The aim of this study was to compare the effect of TIVA with propofol versus ketofol (1:4 ratio) on incidence of emergence agitation in children undergoing tonsillectomy. The aim of this study was to compare the effect of propofol and ketofol (ketamine-propofol mixture) on EA in children undergoing tonsillectomy. Conclusion: Infusion of ketofol in children undergoing tonsillectomy provides shorter recovery time and lower incidence of EA despite the non significant difference with propofol. Comparison of effects of propofol and ketofol (Ketamine-Propofol mixture) on emergence agitation in children undergoing tonsillectomy. Afri Health Sci. 2019;19(1). 1736-1744. https://dx.doi. org/10.4314/ ahs. v19i1.50
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