Abstract
Introduction: Spinal anesthesia is considered a reasonable choice for cesarean section. Bupivacaine and ropivacaine have been used as intrathecal drugs alone or in combination with various opioids. Ropivacaine is considered a valid and safe alternative to bupivacaine for spinal anesthesia.
 Objectives: To compare the efficacy and safety of hyperbaric ropivacaine with hyperbaric bupivacaine in spinal anesthesia for elective cesarean section.
 Methodology: Sixty pregnant women undergoing elective cesarean section were allocated into two groups. Group R received 3 ml of 0.5% hyperbaric ropivacaine (2 ml 0.75% plain ropivacaine mixed with 1 ml of 25 %dextrose) and Group B received 2.5 ml of 0.5% hyperbaric bupivacaine. Both the groups were compared in terms of onset of sensory and motor block, regression of sensory and motor block, duration of analgesia and side effects.
 Results: The onset of sensory block was comparable in both groups but was statistically insignificant. The onset of motor block in Bupivacaine(7.53 ± 1.72) min was faster when compared to Ropivacaine group(14.33 ± 6.19) min. Regression of sensory and motor block both were faster in Ropivacaine group. Duration of analgesia was longer in Bupivacaine group(131.17 ± 32.95)min than Ropivacaine group(125.33 ± 30.54)min.
 Conclusion: Ropivacaine can be used as an alternative to Bupivacaine for spinal anesthesia in cesarean section but has a shorter duration of sensory and motor block.
Highlights
The objec ve of an anesthesiologist is to make the pa ent free of pain, during both surgical procedure and postopera ve period since the outcome of untreated pain and inadequate anesthesia can be devasta ng.[1]
Ropivacaine can be used as an alterna ve to Bupivacaine for spinal anesthesia in cesarean sec on but has a shorter dura on of sensory and motor block
This study demonstrated that 0.5% hyperbaric ropivacaine can be used as an alterna ve to 0.5% hyperbaric bupivacaine in spinal anesthesia for elec ve cesarean delivery but with shorter dura on of sensory and motor block
Summary
The objec ve of an anesthesiologist is to make the pa ent free of pain, during both surgical procedure and postopera ve period since the outcome of untreated pain and inadequate anesthesia can be devasta ng.[1] Adequate analgesia enables early rehabilita on and reduces hospital stay by restoring normal func ons like ven la on, coughing and mobility.[2] Several op ons are available for intraopera ve anesthesia as well as postopera ve analgesia.[3] spinal and epidural analgesia, wherever possible using local anesthe cs with or without addi ves are among them They provide dis nct benefits over other modali es like general anesthesia and peripheral nerve blocks.[4]. Though they have same mechanism of ac on as other local anesthe cs, there are some differences in their structural, physiochemical, pharmacokine c and pharmacodynamic proper es.[6,7,8] Ropivacaine is enan omerically pure (S-enan omer), whereas, Bupivacaine is a racemic mixture of two (R and S) enan omer of same class, structurally related to bupivacaine, but with fewerneurotoxicity and cardiac toxicity .9
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