Comparison of effects between high-flux hemodialysis and low-flux hemodialysis

Abstract

Objectives To compare the total effect on clearing uremic toxins and changing of clinical symptom between high-flux hemodialysis (HFHD) and low-flux hemodialysis. Methods The patients (n = 32)with maintaining hemodialysis were divided into HFHD group(n = 16) and LFHD group(n = 16) at random. HFHD group and LFHD group was given treatment fifth every two weeks (4. 5 hours per time), respectively. Their plasma levels of BUN 、eatinine(Cr) 、K + 、Na + 、Ca2 + 、P3+ 、β2-microglobulin(β2-MG) 、 albumin(Alb) and iPTH , and so on ,were detected before the treatment and at the end of the treatment. Meanwhile, changing of their clinical symptoms were observed. The data of two groups were compared after one year. Results The clearance rates of β2-MG and iPTH were significantly higher in HFHD group than in LFHD group(p ＜ 0. 05). 2. There were no significant differences in serum urea 、Cr 、KT/V and albumin between two groups(p ＞ 0. 05). 3. There were no significant differences in the improvement of K + 、Na + 、Ca2 + 、P3+ between the two groups(p ＞ 0. 05). 4. The clinical symptoms were significantly improved in HFHD group. Conclusions HFHD is better than LFHD in the clearance of larger molecules such asβ2-MG and iPTH. The clearance of small molecules is the same effect between the two groups. HFHD can improve patient's clinical symptoms and cant lose more Alb. Key words: Hemodislysis