Abstract
Rationale Respiratory syncytial virus (RSV) is one of the major aggravating factors of asthma and RSV-bronchiolitis tend to develope into bronchial asthma. We investigated whether ECP, RANTES and eotaxin contribute to pathogenesis of bronchiolitis. Methods We identified viral agent in nasopharyngeal secretion (NPS) by indirect IF assay and 28 patients defined as RSV(+) bronchiolitis, 11 patients as RSV(-) bronchiolitis and 7 children as control. ECP, RANTES, eotaxin were measured by ELISA in serum and NPS. Results The ECP levels of bronchiolitis in NPS were significantly higher than in serum (p<0.001). The ECP in NPS of both RSV(+) and RSV(−) group were significantly higher than control (p=0.001, p=0.012) and also more increased in RSV(+) than RSV(−) group (p=0.033). Serum RANTES are 1000 times much higher than that in NPS and RANTES of bronchiolitis were higher than control in NPS (p=0.014). Serum eotaxin levels were higher than that in NPS (p<0.001). Conclusions Chemokines in NPS were more accurate than in serum for reflecting RSV-induced inflammation. RANTES, eotaxin and ECP which is important in the pathogeneis of asthma were increased in RSV-bronchiolitis and the level of chemokine in NPS was more accurate marker of airway inflammations.
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