Abstract

In this paper, we analyze the dynamical behavior of the delayed fractional-order tumor model with Caputo sense and discretized conformable fractional-order tumor model. The model is constituted with the group of nonlinear differential equations having effector and tumor cells. First of all, stability and bifurcation analysis of the delayed fractional-order tumor model in the sense of Caputo fractional derivative is studied, and the existence of Hopf bifurcation depending on the time delay parameter is proved by using center manifold and bifurcation theory. Applying the discretization process based on using the piecewise constant arguments to the conformable version of the model gives a two-dimensional discrete system. Stability and Neimark–Sacker bifurcation analysis of the discrete system are demonstrated using the Schur-Cohn criterion and projection method. This study reveals that the delay parameterτin the model with Caputo fractional derivative and the discretization parameterhin the discrete-time conformable fractional-order model have similar effects on the dynamical behavior of corresponding systems. Moreover, the effect of the order of fractional derivative on the dynamical behavior of the systems is discussed. Finally, all results obtained are interpreted biologically, and numerical simulations are presented to illustrate and support theoretical results.

Highlights

  • Cancer is a very complex system as it integrates around two hundred different diseases with different characteristics and so, it is the leading cause of mortality worldwide

  • We add an extra delay parameter to model (1.2), and we consider the fractional form of this model with both Caputo and conformable sense, which are given as model (1.5) and model (1.7), respectively

  • We note that we use piecewise constant arguments in model (1.7) instead of the delay parameter in model (1.5)

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Summary

Introduction

Cancer is a very complex system as it integrates around two hundred different diseases with different characteristics and so, it is the leading cause of mortality worldwide.

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