Abstract
Purpose: Tissues in the joint express a large amount of extracellular matrix (ECM) which interferes with transfecting agents. Currently employed methods do not result in a satisfactory transfection of ECM-rich tissue. Biodegradable and bioresponsive polymer-based nanoparticles (Nanogel, 20Med Therapeutics) can be used as an oligonucleotide delivery technology and be optimized for transfection of specific cells. This makes it a promising candidate for in vivo delivery of osteoarthritis-modulating mRNA drugs.
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