Comparison of Different Methods for Carbohydrate Disorder Detection

Abstract

Measurement of fasting glucose and prandial glucose, as well as glycated haemoglobin (HbA1c) and oral glucose tolerance test (OGTT) could confirm diabetes or impaired glucose tolerance but they are invasive and time consuming methods. Some new technologies assessing dermal changes in perspiration like EZscan are used for defining carbohydrate state. We compare common methods used for detecting carbohydrate disorders with EZscan methodology assessing their potency to reveal diabetic and prediabetic patients. We studied 124 patients (64 males, 60 females, mean age 43.4±8.9years) with very high risk for diabetes. In these patients we measured HbA1c and performed OGTT and diagnosis diabetes or prediabetes was based on general recommendations. In addition patients underwent EZscan test in which diagnosis is based on measurement of electrochemical skin conductance. Only in 37 patients (29.8%) HbA1c was above 6.5% and in another 38 patients (30.6%) HbA1c was between 6.0-6.49%. After performing OGTT 22 patients (17.7%) were defined with increased fasting glucose (IFG) and 37 patients (29.8%) were with impaired glucose tolerance (IGT), 58 patients (46.7%) were with diabetes. Results from EZscan test show that 65 patients (52.4%) are with IFG/IGT and 55 patients (44.3%) are with diabetes. Age and gender did not have influence on the results. We conclude that EZscan could be used as test with similar to OGTT power for diagnosis of diabetes. HbA1c shows least potency for diagnosis. EZscan presents with some additional advantages being noninvasive method, taking no more than five minutes, with no need of special condition. Disclosure I. Daskalova: None. T. Totomirova: None. N. Petrov: None.