Abstract
AimThis systematic review and meta-analysis was carried out to compare the diagnostic accuracy of Magnetic resonance elastography (MRE) and Fibroscan for detecting liver fibrosis in Chronic Hepatitis B (CHB) patients.MethodsThe PubMed, the Cochrane Library, and the Web of science databases were searched for studies that evaluated the diagnostic value of MRE and Fibroscan for liver fibrosis in CHB patients until March 1st 2017. The quality of the included studies was assessed by the revised Quality Assessment for Studies of Diagnostic Accuracy tool (QUADAS-2). Meta-disc 4.1 was used to summary the area under receiver operating characteristics curve (AUROC), sensitivity, specificity, diagnostic odds ratios to assess the accuracy of staging liver fibrosis using MRE and Fibroscan.ResultsA total of nine MRE studies with 1470 patients and fifteen Fibroscan studies with 3641 patients were included in this systematic review. The summary AUROC values using MRE and Fibroscan for detecting significant fibrosis, advanced fibrosis and cirrhosis were 0.981 vs. 0.796(p<0.001), 0.972 vs. 0.893(p<0.001), and 0.972 vs. 0.905 (p<0.001). The pooled sensitivity and specificity using MRE for the diagnosis of significant fibrosis, advanced fibrosis and cirrhosis were 92.8% and 93.7%, 89.6% and 93.2%, 89.5% and 92.0%, respectively. The pooled sensitivity and specificity using Fibroscan for the diagnosis of significant fibrosis, advanced fibrosis and cirrhosis were 71.6% and 81.6%, 79.0% and 84.6%, 80.0% and 86.6%, respectively.ConclusionMRE is more accurate than Fibroscan in diagnosing liver fibrosis in CHB patients, especially in diagnosing significant fibrosis and advanced fibrosis.
Highlights
Liver fibrosis is a vital wound-healing response during the process of progression from chronic hepatitis B (CHB) to cirrhosis[1]
Magnetic Resonance Elastography (MRE) is more accurate than Fibroscan in diagnosing liver fibrosis in CHB patients, especially in diagnosing significant fibrosis and advanced fibrosis
The PubMed, the Cochrane Library, and the Web of Science databases were searched for studies, which evaluated the diagnostic value of MRE and Fibroscan for liver fibrosis in CHB patients until March 1st 2017
Summary
Liver fibrosis is a vital wound-healing response during the process of progression from chronic hepatitis B (CHB) to cirrhosis[1]. It can be found in most of the CHB patients. Liver biopsy has long been considered the “gold standard” for determine the stages of liver fibrosis, it cannot be widely used in clinical practice for its limitations and risks, such as sample errors, poor tolerance, high cost and risk of hemorrhage, etc. Magnetic Resonance Elastography (MRE) is a new elastography method, which has been developed to improve the accuracy of diagnostic of liver fibrosis. The present meta-analysis aims to compare the diagnosis accuracy of MRE and Fibroscan for detecting liver fibrosis in CHB patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
