Comparison of dexmedetomidine and clonidine with ropivacaine in epidural anaesthesia in vaginal hysterectomies

Abstract

Background The present randomized double blind prospective study was carried out for Comparison of Dexmedetomidine and Clonidine along with Ropivacaine in epidural anaesthesia for vaginal hysterectomy. Methods: 60 female patients of ASA grade I and II, between the age group of 45 - 60 years were randomly assigned to 2 groups. Group RD: received 17 ml of 0.75% Ropivacaine and 1.5μg/kg of Dexmedetomidine , Group RC: received 17 ml of 0.75% Ropivacaine and 2μg/kg of Clonidine in supine position via epidural catheter. Onset, quality, duration of sensory and motor block and hemodynamic parameters evaluated. Results: Patients from Group RD have fast sensory block onset (i.e. 9.96±0.61min), prolonged two seg. regression time (138.93±4.48) and prolonged Analgesia time ((i.e 353.9±4.03min) as compared to Group RC i.e. (12.4±0.77), (128.8±3.46),(308.06±5.47) respectively. The duration of motor blockade was prolonged in patients of group RD (242.23±5.72min) as compared to the patients in group RC (230.66±5.20min). Patients in group RD were more sedated as compared to the patients in group RC. Initial fall in heart rate was more in patients of RD group as compared to the patients of group RC but later on both the groups showed stable heart rate.