Abstract
1. Several microsomal mono-oxygenase activities, as well as glutathione-dependent detoxication reactions, were measured in the midgut and fat body throughout fifth instar development of Manduca sexta. 2. Microsomal mono-oxygenase activity, indicated by several parameters, was demonstrated in fat body and midgut throughout the instar; activity generally increased to late instar then declined in the prepupa. 3. Spectral evidence indicated a qualitative difference between midgut and fat body microsomal cytochrome P-450. 4. Phenobarbital and 3-methylcholanthrene induced microsomal oxidase activity in both tissues.
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