Abstract
ABSTRACTObjectives:To compare the levels of cortisol in patients of vasovagal syncope (VVS) and postural tachycardia syndrome (POTS).Methods:A cross-sectional analytical study was conducted at Islamic International Medical College, Rawalpindi and Electrophysiology Department at (AFIC). This study included 80 subjects, comprising of 35 patients in each group of vasovagal syncope and postural tachycardia syndrome and 10 healthy subjects. Patients with complaint of syncope was evaluated for vasovagal syncope and postural tachycardia syndrome using Head Up Tilt Test (HUTT. Blood samples of all the participants were taken and serum cortisol was analyzed using ELISA method. Results were analyzed on SPSS Statistics 21 using ANOVA with a p value of ≤0.05 regarded as significant.Results:Hormonal analysis shows that cortisol levels in the vasovagal, postural tachycardia syndrome and in control group was 153±16.7pg/ml, 160.17±pg/ml, and 69.65± 5.8pg/ml respectively. Cortisol levels were significantly higher in both vasovagal and POTS groups as compared to controls with a p-value of 0.04 and 0.023 respectively. However, there was no significant difference between vasovagal and POTS patients with p value 0.570.Conclusion:It is concluded from the study that cortisol responses of VVS and POTS were positive.
Highlights
Sudden loss of consciousness with inability to maintain postural tone is known as syncope
The present study aims at determining the association of cortisol levels with vasovagal syncope and postural tachycardia syndrome (POTS)
The study comprised a total of 80 patients with 35 patients in each group of vasovagal syncope and postural tachycardia syndrome diagnosed on head up tilt test
Summary
Sudden loss of consciousness with inability to maintain postural tone is known as syncope. This is due to cerebral hypo-perfusion for short duration of time on the average 12 seconds.[1] Prevalence of syncope is 42% with incidence of 6% per annum.[2] There are many causes of syncope such as Reflex, Cardiac, Neurological, Endocrinological and Psychiatric illnesses. The vasovagal syncope is the most frequent type of syncope which is mediated by orthostatic and emotional stress.[2,3,4] Another type mimicking vasovagal syncope is POTS. It is a heterogeneous disorder that disturbs normal autonomic control.[5,6] Neurally mediated reflex syncope
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