Abstract
Purpose To compare differences in central corneal thickness (CCT), corneal curvature, and other corneal measurements of children with diabetes mellitus (DM) and healthy children, and to investigate related factors. Methods This was a case-control study. From January to February 2018, 50 children with diabetes mellitus were selected as a case group, and 46 healthy children and adolescents without diabetes mellitus were selected as a control group. Corneal topography and CCT were analyzed using a corneal topography measuring apparatus and biometrics (IOL Master). In the diabetic group, we analyzed whether age, course of disease, sex, glycosylated hemoglobin, triglyceride level, total cholesterol, body mass index (BMI), parental BMI, birth history, feeding history, pregnancy, or puerperal history were related to corneal morphology. Results There was a significant difference in CCT between groups, but no significant differences were found in corneal diameter, corneal curvature R1 or R2, or corneal topography. Central corneal thickness was not correlated with other clinical factors in the diabetes group. Conclusion Early screening and close follow-up of keratopathy in children with diabetes are imperative.
Highlights
To compare differences in central corneal thickness (CCT), corneal curvature, and other corneal measurements of children with diabetes mellitus (DM) and healthy children, and to investigate related factors
We analyzed whether age, course of disease, sex, glycosylated hemoglobin, triglyceride level, total cholesterol, body mass index (BMI), parental BMI, birth history, feeding history, pregnancy, or puerperal history were related to corneal morphology
Results. ere was a significant difference in CCT between groups, but no significant differences were found in corneal diameter, corneal curvature R1 or R2, or corneal topography
Summary
Comparison of Corneal Parameters of Children with Diabetes Mellitus and Healthy Children. Journal of Ophthalmology the increasing number of children and adolescents with diabetes mellitus, the results of corneal change, and risk factors in this population are of social significance and becoming more and more valuable. Is paper describes a case-control study conducted in Shanghai, China, with the aim of providing reference data for the prevention and treatment of keratopathy in children and adolescents with diabetes mellitus. Materials and Methods is was a hospital-based case-control study (clinicaltrials.gov identifier: NCT03587948) It is a part of Shanghai Children and Adolescent Diabetes Eye study (SCADE) [10]. (2) If no typical symptoms are present but fasting blood glucose > 7 mmol/l, or postprandial blood glucose > 11.1 mmol/l, the test is performed twice and those who still reach the above values are diagnosed with diabetes mellitus.
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