Comparison of Cord Blood Lipid Profile in Preterm Small for Gestational Age and Appropriate for Gestational Age Newborns.

Abstract

Coronary heart disease is one of the major causes of morbidity and mortality in current era. The roots of this epidemic have been traced to as early as foetal life by foetal origin hypothesis. There are a few studies which have compared the cord blood lipid profile of preterm and term babies and thereby leading a path to primordial prevention of chronic diseases. To study cord blood lipid profile of preterm appropriate for gestational age and preterm small for gestational age neonates and compare atherogenic index of both groups. This cross-sectional study was conducted in 109 preterm infants. Cord blood samples were collected from placental side of umbilical cord at birth and analyzed for lipid profile which includes serum cholesterol, triglycerides, Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and apolipoproteins which include ApoA1, Apo B. Preterm Small for Gestational Age (SGA) neonates had statistically significant higher values of triglycerides, Apo B and atherogenic index compared to preterm Appropriate for Gestational Age (AGA) neonates. Other measured lipid levels were not statistically significant, though the values were higher than reference ranges for term babies. Prematurity as a factor associated with a more atherogenic lipid profile is re-affirmed and SGA as an additional risk factor has been proven giving scope for future research and primordial prevention.