Comparison of contrast-enhanced ultrasound targeted biopsies versus standard systematic biopsies for prostate cancer detection in different PSA value groups in rural China

Abstract

Objective To investigate prostate cancer detection rate of different biopsy protocols in different PSA value groups in rural China. Methods A total of 186 patients underwent contrast-enhanced ultrasound (CEUS) in order to determine the puncture target prior to biopsy were enrolled in this retrospective study. All patients underwent 12-core SB combined with CEUS-TB. The biopsy results of different biopsy protocols were compared in patients with stratification by PSA value. Results In 186 patients underwent prostate biopsy, the histopathologic results revealed prostate cancer in 117 cases (62.9%) and benign lesions in 69 cases (37.1%). The PSA 4-10ng/ml group, the prostate cancer detection rate of 8-core and 12-core method was no statistical significance. But the 12-core method was significantly higher than CEUS-TB (44.9% versus 32.7%, P = 0.01). The PSA 10-20ng/ml group, there was no statistical significance in prostate cancer detection rate between SB and CEUS-TB (50.0% versus 45.7%, P = 0.15). The PSA greater than 20ng/ml group, the prostate cancer detection rate by SB was higher than CEUS targeted biopsy, but there was no statistical significance (79.1% versus 76.9%, P = 0.15). In the overall patients, the biopsy core positive rate of CEUS-TB was significantly higher than SB (97% versus 55.5% and 28.5%, P = 0.0001). Conclusion The flexible use of SB combined with CEUS-TB can reduce the number of biopsy cores in higher PSA groups. It has clinical importance in the detection of prostate cancer in different PSA value groups in rural china.