Abstract
After upper abdominal surgery, 40 patients were randomly allocated to receive either nalbuphine hydrochloride or morphine sulfate in doses sufficient to ameliorate pain. Using the linear analogue score, pain assessment showed no difference in the first hour, but after 3,6, and 20 h, there was more pain relief in the morphine group than in the nalbuphine group. During physiotherapy, pain was significantly less in the morphine group (p < 0.01); however, there was no significant difference in the ability to cough in both groups. Also there was no significant difference in the observed and the patient assessed pain relief. There was more sedation in the nalbuphine group. Respiratory rate was significantly lower in the morphine group (p < 0.05), and the PaCO2 rose significantly in the morphine group (p < 0.01). A larger dose of nalbuphine was required to obtain satisfactory pain relief than with morphine (p < 0.01).
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