Abstract
The decrease in social distance together with the normalization period as of June 1, 2020, in our country caused an increase in the number of coronavirus disease 2019 (COVID-19) patients. Our aim was to compare the demographic features, clinical courses, and outcomes of confirmed and probable COVID-19 patients admitted to our intensive care unit (ICU) during the normalization period. Critically ill 128 COVID-19 patients between June 1, 2020, and December 2, 2020, were analyzed retrospectively. The mean age was 69.7 ± 15.5 y (61.7% male). Sixty-one patients (47.7%) were confirmed. Dyspnea (75.0%) was the most common symptom and hypertension (71.1%) was the most common comorbidity. The mean Acute Physiology and Chronic Health Evaluation System (APACHE II) score; Glasgow Coma Score; Sequential Organ Failure Assessment scores on ICU admission were 17.4 ± 8.2, 12.3 ± 3.9, and 5.9 ± 3.4, respectively. One hundred and one patients (78.1%) received low-flow oxygen, 48 had high-flow oxygen therapy (37.5%), and 59 (46.1%) had invasive mechanical ventilation. Fifty-three patients (41.4%) had vasopressor therapy and 30 (23.4%) patients had renal replacement therapy due to acute kidney injury (AKI). Confirmed patients were more tachypneic (p = 0.005) and more hypoxemic than probable patients (p < 0.001). Acute respiratory distress syndrome and AKI were more common in confirmed patients than probable (both p < 0.001). Confirmed patients had higher values of hemoglobin, C- reactive protein, fibrinogen, and D-dimer than probables (respectively, p = 0.028, 0.006, 0.000, and 0.019). The overall mortality was higher in confirmed patients (p = 0.209, 52.6% vs. 47.4%). Complications are more common among confirmed COVID-19 patients admitted to ICU. The mortality rate of confirmed COVID-19 patients admitted to the ICU was found to be higher than probable patients. Mortality of confirmed cases was higher than prediction of APACHE-II scoring system.
Highlights
The decrease in social distance together with the normalization period as of June 1, 2020 in our country caused an increase in the number of COVID 19 patients
During the period, 342 patients were admitted to intensive care unit (ICU) and 128 of them were diagnosed with COVID-19
Confirmed patients had more comorbidity related to the renal system than probable (p=
Summary
The decrease in social distance together with the normalization period as of June 1, 2020 in our country caused an increase in the number of COVID 19 patients. Our aim was to compare the demographic features, clinical courses and outcomes of confirmed and probable coronavirus disease 2019 (COVID-19) patients admitted to our intensive care unit (ICU) during the normalization period. Mortality of confirmed cases were higher than prediction of APACHE-II scoring system This virus has the characteristics of the beta-coronavirus subgroup from the Coronavirus family. Our aim was to compare the demographic and clinical features, complaints, comorbidities, intubation-mechanical ventilation requirement, treatments, complications, clinical courses, and outcomes of confirmed and probable COVID-19 patients admitted to our ICU during the normalization period. The primary outcome of the study is to determine and compare the incidence of confirmed and probable critically ill COVID-19 patients, the need for intubation-mechanical ventilation and ICU-hospital mortality. The secondary outcome is to compare the complications, laboratory results, length of ICU and hospital stay between confirmed and probable critically ill COVID-19 patients
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