Abstract
Screening programs may be useful to reduce the rate of undetected glaucoma. Compass (CMP, CenterVue, Padova, Italy) Standard Suprathreshold strategy (SST) analyses the visual function at 52 retinal locations. A new Quick Suprathreshold strategy (QST) reduces the number of tested locations to 24. With both tests, the CMP also provides an image of the central retina and a detail of the optic nerve head. The aim of this paper is to measure the performances of SST and QST compared with clinical diagnosis. 63 consecutive healthy subjects and 60 consecutive patients with perimetric defects from glaucoma in both eyes were recruited. They received one test per eye (SST or QST in randomized order); results were classified into normal, suspect and abnormal according to a global index provided in the report and called SupraThreshold Response (STR). Agreement between clinical diagnosis and test output were calculated, and test time was also measured. The agreement with the clinical diagnosis was 95.7% for SST and 95.1% for QST. When two suspect tests were excluded, agreement for QST increased to 96.7%. Test duration was 164 ± 82 s for SST and 71 ± 41 s for QST (p < 0.0001). Such a difference was similar in both glaucoma patients (respectively 231 ± 65 s vs. 105 ± 33 s, p < 0.0001) and normal subjects (98 ± 17 and 39 ± 9 s, p < 0.0001). In conclusion, SST and QST showed similar, high agreement with clinical judgement. Morphological analysis is potentially helpful in further improving the clinical usefulness of suprathreshold tests. QST is characterized by a strong time saving compared with SST.
Highlights
Results of 145 subjects were potentially eligible. 11 glaucoma patients (14 eyes) were excluded suprathreshold tests were classified according to SupraThreshold Response (STR) into normal, suspect, and abnormal
Four normal subjects were excluded due to the presence of defects analysis was repeated by excluding suspect tests, including them into normal results or at standard perimetry, and four because of unreliable test results
Variability of consecutive results is expected due to the psychophysical nature of perimetry [21]
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Glaucoma is the leading cause of irreversible blindness, with more than 70 million people affected in the world and more than 10 million bilaterally blind [1]. As most types of glaucomas are asymptomatic in initial stages, more than half of affected individuals are undetected [2]. Late presentation with the advanced stages of the disease is responsible for late diagnosis and late treatment, with reduced vision-related quality of life, increased social costs [3] and an increased risk of blindness [4]
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