Abstract
1. 1. Adaptation to cold at the cellular level is a necessary condition for mammalian hibernation. The effect of hypothermia on the responses of cortical neurons to L-Glutamate ( L-Glu) in the ground squirrel (GS) Citellus dauricus and the rat was recorded extracellularly. 2. 2. At normal cortical temperatures ( T C), all neurons (rat and GS) were excited by L-Glu, but responses of neurons to L-Glu decreased with lowering temperature. The response of rat cortical neurons disappeared at T C 19.0 ± 0.3°C ( N = 23) in winter. 3. 3. The response of GS cortical neurons also disappeared at T C 20.2 ± 2.3°C ( N = 21) in summer, but persisted at lower T C's during the winter. 4. 4. Results of the present work show that while the cold tolerance of both GS and rat cortical neurons are similar in the summer, cold tolerance in the hibernator is greatly increased during the winter.
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