Abstract
Background: Various chemotherapy protocols for treating lymphoma in dogs have been published; however, comparison of protocols from different studies is difficult, especially when evaluating survival time and toxicoses.Hypothesis: The choice of COAP (C, cyclophosphamide; O, vincristine; A, cytosine arabinoside; P, prednisone) and a modified University of Wisconsin 19‐week (UW‐19) induction protocol has no influence on overall survival times in dogs with lymphoma.Animals: One hundred and one dogs with multicentric lymphoma.Methods: Retrospective study (2001–2006). Dogs induced with either an 8‐week COP‐based protocol (C, cyclophosphamide; O, vincristine; and P, prednisone) with maintenance therapy (COAP group) or a 19‐week CHOP (C, cyclophosphamide; H, doxorubicin; O, vincristine; and P, prednisone) based protocol (UW‐19 group) were compared in terms of the duration of first remission, survival time, toxicoses, and cost.Results: There were 71 dogs in the COAP group and 30 dogs in the UW‐19 group. Various protocols were used after the first relapse. The median duration of the first remission for the COAP and UW‐19 groups were 94 days (range, 6–356 days) and 174 days (28–438 days), respectively (P< .01). The median survival times for dogs in the COAP and UW‐19 groups were 309 days (6–620 days) and 275 days (70–1102+ days), respectively (P= .09). Dogs in the COAP group had a hazard ratio of 1.9 (95% CI 1.1–3.4) for death relative to the UW‐19 group (P= .03), after controlling for the confounders (World Health Organization clinical stage, age, sex, use of doxorubicin during reinduction). The severity of neutropenia and gastrointestinal toxicoses were significantly higher in the UW‐19 group than in the COAP group (P= .01 andP< .01, respectively).Conclusion and Clinical Importance: Use of a long‐term doxorubicin‐containing sequential combination chemotherapy protocol is associated with a decreased risk of relapse and death relative to a non‐doxorubicin‐containing protocol.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
