Abstract
Background: Tinea cruris and corporis are common diseases and can be widespread. Estimated lifetime probability of contracting the disease is as high as 10-20%. Dermatophytic infections are one of the three most frequently observed skin diseases among poor communities in tropical countries. Tea tree oil exerts its antifungal activity by altering membrane properties and compromising membrane associated function resulting in clinical improvement and mycological cure of superficial dermatophytes. Objectives: The aim of this study is to determine the efficacy and safety of tea tree oil 50% in a cream base compared with clotrimazole 1% cream for the treatment of tinea corporis or cruris. Material and Methods: Sixty patients were enrolled in the study and randomized into tea tree oil and clotrimazole groups with 30 patients in each group. Both groups were instructed to apply cream two times a day after cleaning with soap for 4 weeks. The patients were asked to follow-up every 2 weeks for photography, microscopic and clinical assessment. Before enrollment, patient signed a written consent form. Results: Using intention to treat analysis, the assessment of mycological cure, clinical cure, global physician assessments and overall patient perception were done. There were no statistical difference of all the parameters between tea tree oil group and clotrimazole group. Conclusion: Tea tree oil 50% cream is safe and as effective as clotrimazole 1% cream for the treatment of tinea corporis or cruris.NJDVL Vol. 13, No. 1, 2015 Page: 24-30
Highlights
Tinea corporis is a superficial cutaneous fungal infection clinically characterized by annular plaques, usually sharply marginated with raised borders and mild scales
There were no statistical difference of all the parameters between tea tree oil group and clotrimazole group
Dermatophytic infections are one of the three most frequently observed skin diseases among poor communities in tropical countries.3It is commonly caused by Trichophyton rubrum, T. mentagrophytes and Epidermophyton floccosum
Summary
Tinea corporis is a superficial cutaneous fungal infection clinically characterized by annular plaques, usually sharply marginated with raised borders and mild scales. Single lesions or multiple annular patches to plaques may occur.[1] Tinea cruris and tinea corporis are common and widespread. Dermatophytic infections are one of the three most frequently observed skin diseases among poor communities in tropical countries.3It is commonly caused by Trichophyton rubrum, T. mentagrophytes and Epidermophyton floccosum. Topical azoles and allylamines show high rates of clinical efficacy. These agents inhibit synthesis of ergosterol, which is a major fungal cell membrane sterol. Tinea cruris and corporis are common diseases and can be widespread. Dermatophytic infections are one of the three most frequently observed skin diseases among poor communities in tropical countries. Tea tree oil exerts its antifungal activity by altering membrane properties and compromising membrane associated function resulting in clinical improvement and mycological cure of superficial dermatophytes
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