Comparison of clinical outcomes of Chinese men and women after coronary stenting for coronary artery disease: a multi-center retrospective analysis of 4,334 patients.

Shrestha Rajiv,Xu Tian,Din Shiqing,Liu Zhizhong,Xu Jing,Li Feng,Zhang Aiping,Xie Dujiang,Liu Yueqiang,Yang Song,Ye Fei,Chen Shaoliang,Qian Xuesong

doi:10.7555/jbr.28.20120127

Abstract

The outcome differences between Chinese male and female patients within one-year follow-up after percutaneous coronary intervention (PCI) with stent remain unclear. The present study was aimed to compare clinical outcomes in such two populations. From May 1999 to December 2009, 4,334 patients with acute myocardial infarction (MI), unstable angina, stable angina, or silent ischemia, who underwent PCI, were registered at our centers. Among these, 3,089 were men and 1,245 were women. We compared these groups with respect to the primary outcomes of MI and secondary outcomes including a composite of major adverse cardiac events (MACE) including cardiac death, MI, target lesion revascularization, target vessel revascularization (TVR), stent thrombosis (ST), definite ST and probable ST at one-year follow-up. Chinese male patients had a higher MACE rate (13% vs. 10.7%, P = 0.039), mainly led by TVR (9.09% vs. 6.98%, P = 0.024) at one year, which was significantly different than female patients. Chinese male and female patients showed a significant difference on MACEs. However, there was no significant difference with respect to MI between these groups.

Highlights

Percutaneous coronary intervention (PCI), first introduced as percutaneous transluminal coronary angioplasty (PTCA) by Andreas Gruntzig in 1997, is a catheter-based therapy alternative to open heart surgery
Male patients were found to have a greater incidence of segment elevation myocardial infarction (STEMI) (P, 0.05) and NSTEMI, whereas stable angina and unstable angina incidence was found to be greater in female patients (P, 0.05)
There was a significant difference in myocardial infarction (MI) and target lesion revascularization (TLR) between male and female patients during one-month follow-up

Summary

Introduction

Percutaneous coronary intervention (PCI), first introduced as percutaneous transluminal coronary angioplasty (PTCA) by Andreas Gruntzig in 1997, is a catheter-based therapy alternative to open heart surgery. This study attempts to compare differences in one-year outcomes between genders after PCI by using a large cohort of patients. Secondary endpoints included composite major adverse cardiac events (MACE), such as cardiac deaths, MI, target lesion revascularization (TLR), target vessel revascularization (TVR), stent thrombosis (ST), definite ST and probable ST at one-year follow-up.

Results

Conclusion