Abstract

Immunoglobulin replacement can be life-saving for certain individuals with immunodeficiencies. Several options for IgG replacement exist, including preparations of both intravenous (IVIG) and subcutaneous IgG (SCIG) replacement. SCIG administration is an increasingly used method of replacement with potential advantages including fewer systemic side effects, no need for IV access, patient-reported improved quality of life, and decreased cost. In addition, patients with associated co-morbidities, for instance, those that cause protein loss, may demonstrate more stable, consistent IgG levels on subcutaneous replacement when compared to intravenous replacement.

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