Comparison of clinical outcomes and characteristics between patients with and without hypertension in moyamoya disease

Abstract

ObjectiveOur study aimed to compare the disparity of patients with moyamoya disease (MMD) between hypertension group and non-hypertension group. And we attempt to explore the risk factors for MMD with hypertension. MethodsWe retrospectively analyze 542 adult patients with moyamoya disease admitted to our hospital from 2009 to 2016. In view of inclusion criteria, we divided patients with moyamoya disease into two groups (hypertension group and non-hypertension group) and summarized their clinical characteristics. Furthermore, we explore the risk factors for unfavorable outcomes in hypertension group. ResultsOf 542 adult patients with moyamoya disease, we identified 156 patients (28.8%) with hypertension and 386 patients (71.2%) without hypertension. During follow-up, we hold the views that the prognosis of non-hypertension group was obviously better than hypertension group (P = 0.005) and the complications were prone to occurring to patients with hypertension (P = 0.037). In the multivariate analysis, severe hypertension (OR, 2.746; 95% CI, 1.096–6.822; P = 0.031) and no anti-hypertensive medication (OR, 0.342; 95% CI, 0.131–1.895; P = 0.029) were the independent predictors for postoperative unfavorable outcomes. The common surgical modalities of moyamoya disease (direct and indirect bypass) had no significant difference in future unfavorable outcomes prevention in adult MMD patients with hypertension. ConclusionsWe suggested severe hypertension and no anti-hypertensive medication as the independent risk factors for unfavorable clinical outcomes in adult MMD with hypertension.