Comparison of Clinical Efficacy of Bio-Resorbable Xenogeneic Peritoneal Membrane with Connective Tissue Graft in the Management of Gingival Recession Defects: A Randomized Controlled Clinical Trial.

Abstract

This randomized controlled trial was aimed to determine the clinical efficacy of xenogeneic collagen membrane derived from porcine peritoneum (XCM) in combination with a coronally advanced flap (CAF) in the management of gingival recession defects and to compare the outcomes to those of connective tissue graft (CTG). 12 systemically healthy individuals presenting with 30 isolated/multiple Cairo's RT 1/2 gingival recession defects in maxillary canines and premolars, were randomly treated either with CAF+XCM or CAF+CTG. Recession height (RH), gingival biotype (GB), gingival thickness (GT), width of keratinized gingiva (WKG) and attached gingiva (WAG) were recorded at baseline, 3, 6 and 12 months. Patient perception for pain, esthetics and modification of root coverage esthetic score (MRES) were also documented. From baseline to 12 months, both groups showed a significant reduction in mean RH (CAF+CTG: 2.73±0.79mm to 0.33±0.61mm and CAF+XCM: 2.73±0.88mm to 1.20±0.77mm). At 12 months, CAF+CTG sites had a MRC of 85.60±28.74%, whereas CAF+XCM sites had a MRC of 55.13±31.22%. CAF+CTG treated sites had significantly better outcomes, with greater number of sites achieving complete root coverage (n=11) and higher MRES scores than porcine peritoneal membrane group (P<0.05). Int J Periodontics Restorative Dent. doi: 10.11607/prd.6232.