Comparison of clinical efficacy and impacts on immune function of laparoscopic and open surgery in treatment of colorectal cancer

Abstract

Objective To compare the clinical efficacy and impacts on immune function of laparoscopic and open surgery in treatment of colorectal cancer. Methods From January 2014 to June 2016, clinical data of 156 patients with colorectal cancer were analyzed retrospectively, including 78 cases in laparoscopy group and 78 cases in laparotomy group. Clinical data were analyzed by using statistical software SPSS 17.0. Measurement data such as operation effect indicators, post-operative recovery indicators and immune function related indicators were expressed as mean±standard deviation, and were examined by using t test. Count data, such as postoperative complication rate, were expressed as % , and were examined by using χ2 test. A P value <0.05 was considered as statistically significant difference. Results In the aspect of operation effect indicators: the length of incision, intraoperative blood loss in laparoscopy group were significantly less (shorter) than those of the laparotomy group (P 0.05). In terms of post-operative recovery indicators: the analgesia time, first flatus time, groud activity time and the average hospitalization time in laparoscopy group were significantly less than those of the laparotomy group (P 0.05). There was no significant difference of immune function related indicators between the two groups before operation. The levels of CD3+ , CD4+ , CD4+ /CD8+ were significantly lower, CD8+ , CRP, IL-6 were significantly higher after operation (P<0.05). The immune related indicators in laparoscopy group were significantly better than those in laparotomy group (P<0.05). Conclusion Laparoscopic in the treatment of patients with colorectal cancer is feasible and safe, and has the benefits of less intraoperative blood loss, quicker postoperative recovery, exerts a less negative influence on the immune system compared with open surgery. Key words: Colonic Neoplasms; Laparoscopy; Laparotomy; Immunity; Treatment Outcome