Abstract
BackgroundThe aim of this study was to evaluate the clinicopathological factors and prognosis of mucinous carcinoma (MC) with infiltrative invasion, MC with expansile invasion, and high-grade serous carcinoma (HGSC).MethodsCases of MC and HGSC between 1984 and 2019 were identified. The clinicopathological factors and prognosis of MC with infiltrative invasion or expansile invasion and HGSC were retrospectively compared. Although our present study included cases in our previous studies, we extended observational period when analysis was performed. Accordingly, our study added increased cases and survival analysis was newly conducted.ResultsAfter pathological review, 27 cases of MC with infiltrative invasion, 25 cases of MC with expansile invasion, and 219 cases of HGSC were included. MC had a better prognosis in terms of progression-free survival (PFS, p < 0.01) and overall survival (OS, p < 0.01) than HGSC for all International Federation of Gynecology and Obstetrics (FIGO) stages; however, multivariate analysis did not show statistical differences in PFS and OS. There were no statistically significant differences in PFS and OS for all FIGO stages between MC with infiltrative invasion and HGSC. However, in cases with FIGO stages II to IV, MC with infiltrative invasion had worse PFS (p < 0.01) and OS (p < 0.01) than HGSC. In univariate analysis, MC with infiltrative invasion was a worse prognostic factor for PFS (hazard ratio [HR] 2.83, p < 0.01) and OS (HR 3.83, p < 0.01) than HGSC. Compared with HGSC, MC with expansile invasion had better PFS (p < 0.01) and OS (p < 0.01). Multivariate analysis demonstrated that MC with expansile invasion was a better prognostic factor for PFS (HR 0.17, p < 0.01) and OS (HR 0.18, p = 0.03) than HGSC.ConclusionsCompared to the prognosis of HGSC, that of MC was different according to the invasive pattern and FIGO stage. Therefore, future study may be needed to consider this association.
Highlights
The aim of this study was to evaluate the clinicopathological factors and prognosis of mucinous carcinoma (MC) with infiltrative invasion, MC with expansile invasion, and high-grade serous carcinoma (HGSC)
Compared to cases of HGSC, cases of MC at all stages were diagnosed at younger age (p < 0.01) and earlier Federation of Obstetrics and Gynecology (FIGO) stage (p < 0.01), less frequently had positive peritoneal cytology (p < 0.01), had less residual tumor at primary surgery (p < 0.01), and less frequently received taxane-platinum therapy (p < 0.01) (Table 1)
MC had a better prognosis in terms of Progression-free survival (PFS) (Fig. 2A, p < 0.01) and Overall survival (OS) (Fig. 2B, p < 0.01) than HGSC at all stages
Summary
The aim of this study was to evaluate the clinicopathological factors and prognosis of mucinous carcinoma (MC) with infiltrative invasion, MC with expansile invasion, and high-grade serous carcinoma (HGSC). For EOCs, histological subtypes, residual tumor at cytoreductive surgery, International Federation of Obstetrics and Gynecology (FIGO) stage, and chemosensitivity are important prognostic factors [3,4,5]. Histological subtypes are important factors in the management of EOCs. Among EOCs, the incidence of mucinous carcinoma (MC) ranges from 3 to 11% [6, 7]. The invasive patterns of MC have been recognized as an important factor related to tumor aggressiveness, FIGO stage, and prognosis [9,10,11,12]. MC with infiltrative invasion is a worse histological subtype than MC with expansile invasion
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
