Abstract
Mouse embryos were exposed to TCDD in vivo at various stages of organogenesis and with different dose regimes, calculated to give the same maternal tissue concentrations on day 12 of pregnancy. TCDD concentrations in maternal liver correlated well with corresponding concentrations in maternal adipose tissue. Similarly, the incidence of cleft palates (CP), as evaluated on day 18 of pregnancy, correlated well with maternal hepatic TCDD concentrations (on day 12 of pregnancy). These results may be taken as evidence for a direct action of TCDD on the palatal shelves during embryonic development. On the other hand, neither could a correlation of the CP frequency (as evaluated on day 18) with the TCDD concentration in the embryo (on day 12 of pregnancy) be established, nor a correlation between the TCDD concentrations in the embryo and in maternal liver. However, placental transfer of TCDD is so low that the measurements of TCDD in the embryo were rather unreliable.
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