Comparison of Chloroprocaine Versus Lidocaine With Epinephrine, Sodium Bicarbonate, and Fentanyl for Epidural Extension Anesthesia in Elective Cesarean Delivery: A Randomized, Triple-blind, Noninferiority Study

Abstract

(Anesth Analg. 2021;132: 666–675) Neuraxial analgesia is utilized in over 70% of labors in the United States. The authors of this study report a general consensus among their local and nonlocal peers that 3% chloroprocaine or CP, a local anesthetic with a quick preparation time, and 2% lidocaine, epinephrine, bicarbonate, and fentanyl, or LEBF, which needs additional preparation time, have similar onset times when used to convert epidural pain relief to epidural anesthesia for cesarean delivery (CD). To their knowledge, no study has confirmed this assumption. This study analyzes the onset times of CP and LEBF.