COMPARISON OF CELLULAR PROLIFERATION AND MELANOCYTES IN NON-SYNDROMIC AND SYNDROMIC ODONTOGENIC KERATOCYSTS

Abstract

Objective To compare cell proliferation and the presence of melanocytes in non-syndromic and syndromic odontogenic keratocyst (OK). Study Design We studied 20 cases of sporadic OK and 10 cases of OK associated with NBCC. To evaluate cell proliferation and the presence of melanocytes, immunohistochemistry was performed with antibodies against Ki-67 and Melan-A, respectively. Results The OK associated with NBCC presented 23.4% (range 8.6%-36.8%) and the sporadic OK 21.8% (range 7.6%-40.4%) of proliferating cells. This difference was not significant. Cells positive for Melan-A occurred exclusively in 4 of 9 cases of syndromic keratocyst. Conclusions No differences were found in the proliferation between OK associated with NBCC and sporadic. Only in the OK associated with the NBCC, the presence of melanocytes was detected.