Comparison of catalytic activities between esterase and lipase in the synthesis of drugs and flavor and amide compounds

Abstract

The synthesis of drugs, drug intermediates, and flavor and amide compounds by PLE (pig liver esterase) and PPL (pig pancreatic lipase) carried out in this laboratory has been reviewed and their selectivity in the synthesis of compounds compared. A new method of synthesis of paracetamol, a common analgesic drug, using PLE and PPL to overcome the complicated steps for chemical synthesis starting from p-aminophenol, which is an unstable compound, has been discussed. A new route for enzymatic transesterification of geraniol has been efficiently carried out by PLE, and the result was better than PPL.