Abstract
Results Two of the original 46 volunteers were excluded due to ECG irregularities. Data from one further volunteer was incomplete and therefore excluded from the final analysis. Results from the remaining 43 volunteers are in table 1. Global FA was higher in diastole than systole (0.56 v 0.47; p < 0.001). The global endocardial HA was significantly more right-handed in systole than diastole (34° v 25°; p < 0.001). The global mesocardial HA was circumferentially orientated and similar in both diastole and systole (-3° v -2°; p = 0.42). The global epicardial HA was slightly more left-handed in systole than diastole (-35° v -30°; p < 0.001). Global MD was higher in diastole than systole (1.11 v 0.93 × 10mm/s; p < 0.001).
Highlights
In vivo Cardiac Diffusion Tensor Imaging offers the potential to calculate the mean intravoxel myocyte helical angle (HA) and assess the degree of average myocyte organisation with fractional anisotropy (FA)
The mean diffusivity (MD) measurement with this sequence is expected to be independent of the phase at which it is sampled
1.11 ± 0.13 0.93 ± 0.14 finding of a significant difference between systole and diastole may be as a consequence of strain effects which have been reported to distort the diffusion tensor when acquired out with the cardiac ‘sweet spot’[2]
Summary
In vivo Cardiac Diffusion Tensor Imaging (cDTI) offers the potential to calculate the mean intravoxel myocyte helical angle (HA) and assess the degree of average myocyte organisation with fractional anisotropy (FA). It is not known how these parameters compare between different phases of the cardiac cycle
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