Comparison of Boric Acid and Zinc Oxide Ointments with Different Bases in the Treatment of Wounds

Abstract

As a base of boric acid and zinc oxide ointment, white ointment was admitted to the Pharmacopoeia of Japan, Ninth Edition, to have replaced simple ointment. Major reason for the admission of white ointment is its excellent stability, though simple ointment has been highly estimated among many clinicians in such actions as prevention of drying of wounds, clearing of crust and facilitation of epidermis formation. In this study, the effect of boric acid and zinc oxide ointments having simple ointment as base was compared with that of the same agents with white ointment in the treatment of wounds in rabbits. As a result, the former products brought about more rapid healing, producing better healing ratio, histological findings and other records. Stability of boric acid and zinc oxide preparations having simple ointment base was studied in terms of peroxide value by allowing them to stand in cold place (below 5°) and at room temperature for about 100 days, respectively. The preparations stored in cold place proved stable with their peroxide value increased slightly.