Abstract
To study the effect of two composition ratios of nano-hydroxyapatite and collagen (NHAC) composites on repairing alveolar bone defect of dogs. Eighteen healthy adult dogs were randomly divided into three groups. Two kinds of the NHAC composites were prepared according to the constituent ratios of 3:7 and 5:5; immediately after extraction of the mandibular second premolars, each kind of the NHAC composite was implanted into extraction socket, respectively: Group I, nHA/Col = 3:7; Group II, nHA/Col = 5:5 and Group III, blank control group. The bone-repairing ability of the two grafts was separately analyzed by morphometric measurement, X-ray tomography examination and biomechanical analysis at 1st, 3rd and 6th month post-surgical, respectively.The NHAC composites were absorbed gradually after implanting into alveolar bone defect and were replaced by new bone. The ratios of new bone formation of Group I was significantly higher than that of Group II after 3 months (P < 0.05). The structure and bioactive performance can be improved when the ratio between the collagen and the hydroxyapatite was reasonable, and the repairing ability and effect in extraction sockets are obviously better.
Highlights
It is well accepted by the scientific community that the physiological dimensional changes occur on the alveolar ridge after tooth extraction which is one of the most widely performed dental procedures [1,2,3,4,5] and the resorption reaches a mean horizontal reduction of 3.79 mm and mean vertical reduction of 1.24 mm at 6th month [6]
We developed different composition ratios of nanohydroxyapatite and collagen (NHAC) composites that have some features of natural bone in both composition and microstructure
All experimental sites were fully closed with the gingival epithelium though the regions of the extraction socket was depressed compared with the other tissue after two weeks
Summary
It is well accepted by the scientific community that the physiological dimensional changes occur on the alveolar ridge after tooth extraction which is one of the most widely performed dental procedures [1,2,3,4,5] and the resorption reaches a mean horizontal reduction of 3.79 mm and mean vertical reduction of 1.24 mm at 6th month [6] These height (corono-apical) and width (bucco-lingual) alterations in the alveolar bone cannot be prevented by implants placing immediately into the extraction sockets but reduce the level of the resorption [3, 7]. Synthetic calcium phosphate ceramic materials, for instance hydroxyapatite (HA), are widely used as bone grafts due to their similarity in the chemical composition of bone mineral matrix, resulting in superior
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