Abstract
BackgroundA number of published randomized controlled trials have been conducted to evaluate visual performance of blue light-filtering intraocular lenses (IOL) and UV light-filtering intraocular lenses (IOL) after cataract phacoemulsification surgery. However, results have not always been consistent. Therefore, we carried out a meta-analysis to compare the effectiveness of blue light-filtering IOLs versus UV light-filtering IOLs in cataract surgery.Methods and FindingsComprehensive searches of PubMed, Embase, Cochrane Library and the Chinese BioMedical literature databases were performed using web-based search engines. Fifteen trials (1690 eyes) were included for systematic review, and 11 of 15 studies were included in this meta-analysis. The results showed that there were no significant differences in postoperative mean best corrected visual acuity, contrast sensitivity, overall color vision, or in the blue light spectrum under photopic light conditions between blue light-filtering IOLs and UV light-filtering IOLs [WMD = −0.01, 95%CI (−0.03, 0.01), P = 0.46; WMD = 0.07, 95%CI (−0.04, 0.19), P = 0.20; SMD = 0.14, 95%CI (−0.33, 0.60), P = 0.566; SMD = 0.20, 95%CI (−0.04, 0.43), P = 0.099]. However, color vision with blue light-filtering IOLs was significantly reduced in the blue light spectrum under mesopic light conditions [SMD = 0.74, 95%CI (0.29, 1.18), P = 0.001].ConclusionThis meta-analysis demonstrates that postoperative visual performance with blue light-filtering IOLs is approximately equal to that of UV light-filtering IOLs after cataract surgery, but color vision with blue light-filtering IOLs demonstrated some compromise in the blue light spectrum under mesopic light conditions.
Highlights
Cataract is one of the most serious blinding diseases [1]
This meta-analysis demonstrates that postoperative visual performance with blue light-filtering intraocular lenses (IOL) is approximately equal to that of UV light-filtering IOLs after cataract surgery, but color vision with blue light-filtering IOLs demonstrated some compromise in the blue light spectrum under mesopic light conditions
The rationale is that UV lightfiltering IOLs do not protect the retina from phototoxic damage by high-energy, short-wavelength blue light which is thought to contribute to the pathogenesis of agerelated macular degeneration (AMD) [3,4]
Summary
Cataract is one of the most serious blinding diseases [1]. Modern cataract surgery is routinely combined with the implantation of an intraocular lens (IOL). The healthy human crystalline lens gradually becomes yellow as part of the normal ageing process. This yellowing reduces the transmission of blue light, thereby blocking an amount of blue light from reaching the retina [5]. The possibility of retinal exposure to blue light may accelerate AMD [6] To address this potential damage, several blue light-filtering IOLs have been introduced in recent years. Their yellow tint more closely replicates the spectral transmission properties of the aged human crystalline lens than do the UV light-filtering IOLs [7]. We carried out a meta-analysis to compare the effectiveness of blue light-filtering IOLs versus UV light-filtering IOLs in cataract surgery
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