Abstract
After 1 year of heavy drinking, six alcoholic men were hospitalized for 10 weeks of abstinence and studied serially. The removal rate of alcohol and tolbutamide from the blood, the in vivo activity of two liver microsomal enzymes, and alcohol dehydrogenase were determined three times in each subject. When compared, the rates of alcohol and tolbutamide removal were higher on admission than 10 weeks later. Liver alcohol dehydrogenase increased with time, whereas the activity of the two microsomal liver enzymes decreased with time. Thus the drinking alcoholic has both increased drug metabolism and increased drug-metabolizing enzymes and both decrease with time of abstinence. No correlation was found between the removal rate of alcohol in the whole body and alcohol dehydrogenase levels in the liver.
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