Abstract
Background: The interaction between the root canal system and the oral cavity caused by iatrogenic perforations significantly affects the treatment outcome and tooth survival. Objectives: This study was directed to compare the biocompatibility of an experimental tricalcium phosphate cement versus biodentine and mineral Trioxide aggregate used for furcation perforation repair in dogs. Methods: Perforations were done in 60 teeth (premolars and molars) of six adult dogs. Animals were divided randomly into 3 equal groups of 2 animals each according to the post-operative evaluation period of 1 week, 1 month, and 3-months. Each group was further subdivided into 4 subgroups according to either being repaired with the experimental tricalcium phosphate cement (n=6), or Biodentine (n=6), Mineral Trioxide Aggregate (MTA) (n=6), and positive control(n=2). After evaluation periods, tissue blocks were harvested and histologically examined. Results: No statistically significant difference was found regarding bone deposition scores and inflammatory reaction in the three groups after 1 week, 1 month, or 3 months. All three groups showed a statistically significant difference between all three time periods. Regardless of the repair material used, inflammation scores at 1-week showed the highest scores, decreasing over time except for the control group. Conclusion: The experimental material could be considered as a successful treatment option for repairing furcation perforation.
Highlights
The experimental material could be considered as a successful treatment option for repairing furcation perforation
Calcium silicate cement has become the preferred material for repairing dentin defects where the root canal system interacts with the periodontal ligament because of its ability to induce calcium-phosphate precipitate at the interface with the periodontal tissue and biocompatibility, which leads to bone tissue repair
Each group was further subdivided into 4 subgroups according to either being repaired with the experimental tricalcium phosphate cement (n=6), or biodentine (n=6), or mineral trioxide aggregate (MTA) (n=6), or positive control (n=2)
Summary
When MTA was popularized in 1990, it was the material of choice for all dentinal defects due to its biocompatibility and the ability to induce calcium-phosphate precipitate at the tooth tissue interface. This material has some drawbacks, such as slow setting, complicated handling properties [4], and tooth discoloration. Calcium silicate cement has become the preferred material for repairing dentin defects where the root canal system interacts with the periodontal ligament because of its ability to induce calcium-phosphate precipitate at the interface with the periodontal tissue and biocompatibility, which leads to bone tissue repair. The interaction between the root canal system and the oral cavity caused by iatrogenic perforations significantly affects the treatment outcome and tooth survival
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