Abstract
Objective:To study and compare the clinical effects of azithromycin and erythromycin on children with mycoplasma pneumonia.Methods:Total 132 children with mycoplasma pneumonia who were admitted to our hospital between November 2017 and September 2018 were selected as the research subjects. All the children were divided into an observation group and a control group according to random number table, 66 each. The observation group was treated with azithromycin, while the control group was treated with erythromycin. The therapeutic effect, incidence of adverse reactions and disappearance time of clinical symptoms were compared between the two groups.Results:The total efficacy of the observation group was 98.04%, and that of the control group was 74.51%; there was a significant difference (X2=7.184, P=0.007). The incidence of adverse reactions in the observation group was 15.69%, significantly lower than that in the control group (41.18%) (X2=6.376, P=0.002). The disappearance of fever, cough, rale and X ray shadow of the observation group was significantly earlier than that of the control group, and the difference was statistically significant (P<0.05).Conclusion:Compared with erythromycin, azithromycin is more effective in the treatment of mycoplasma pneumonia in children. Azithromycin can further shorten the improvement time of clinical symptoms and signs and has few adverse reactions and high safety. It is worth clinical application.
Highlights
Mycoplasma pneumonia is a common respiratory disease caused by mycoplasma pneumoniae.[1,2] It is reported that the main clinical manifestations of mycoplasma pneumonia include fever, expectoration, anorexia, headache, sore throat, etc
It has been found that the clinical symptoms of mycoplasma pneumonia in patients are related to the age of patients, and the smaller the age, the more atypical the clinical symptoms of mycoplasma pneumonia.[3,4]
This study compared the clinical efficacy of azithromycin and erythromycin through treating children with mycoplasma pneumonia, with the intention of providing a reference for clinics
Summary
Mycoplasma pneumonia is a common respiratory disease caused by mycoplasma pneumoniae.[1,2] It is reported that the main clinical manifestations of mycoplasma pneumonia include fever, expectoration, anorexia, headache, sore throat, etc. It has been found that the clinical symptoms of mycoplasma pneumonia in patients are related to the age of patients, and the smaller the age, the more atypical the clinical symptoms of mycoplasma pneumonia.[3,4]. The pathogenesis of mycoplasma pneumonia in children has not been clearly defined clinically, but it is considered being related to autoimmunity and humoral immunity of children.[5,6] the clinical treatment of mycoplasma pneumonia in children is mainly. The most commonly used drugs are macrolide antibiotics. Azithromycin and erythromycin are macrolide antibiotics, which have good inhibitory effect on mycoplasma.[7,8] This study compared the clinical efficacy of azithromycin and erythromycin through treating children with mycoplasma pneumonia, with the intention of providing a reference for clinics
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