Abstract
The in vitro release of the drug components from salicylic acid and sodium salicylate tablets was studied. Comparisons were made concerning the availability of sodium ions and salicylate ions from typically formulated tablets containing the salt of the drug. Similarly formulated salicylic acid tablets were also compared. The availability of sodium from the sodium salicylate tablets, while unaffected by pH, was substantially different from that of the salicylate ion and would represent the inherent disintegration-deaggregation-dissolution behavior due to the tablet formulation itself.
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